In particular, metabolic dysfunction-associated steatotic liver disease (MASLD, formerly known as NAFLD) represents a new challenge for the healthcare system.

In order to name the disease more clearly and prevent stigmatisation, the liver associations from Europe, the USA and Latin America have jointly decided to change the technical terms for fatty liver disease. This decision was also supported by patient organisations worldwide. (

MASLD is primarily caused by too little exercise combined with an excessively high energy intake. It can therefore be described as a lifestyle-induced disease. It is estimated that one in three people in Germany has steatosis, which develops into metabolic dysfunction-associated steatohepatitis (MASH) in up to 5% of those affected. Progressive MASH can have far-reaching health complications such as cirrhosis or liver cancer. No medication has been authorised to date. The most important intervention for those affected is a permanent change in lifestyle.

In addition, half of MASLD patients have other diseases and metabolic disorders such as dyslipidaemia (50%) and type 2 diabetes mellitus (60%). Patients are also frequently affected by obesity (72%, BMI>30kg/m2 ) and hypertension (78%) (see Alsenbesy M et al. Z Gastroenterol 2019; 57: 1209-1217).

Examples of our project work


The GBA-funded innovation project offers the first opportunity to develop lifestyle interventions tailored to the needs of MASH patients.

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MASLD/MASH milieu study

How can you develop motivating, target group-specific communication that works sustainably for MASLD/MASH patients?


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Patient guideline EASL

Based on the clinical guideline of the EASL on NAFLD/NASH, a patient guideline was developed that explains fatty liver and its causes, consequences and (non) medical treatment options in a simple and patient-understandable way.

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Gender-appropriate language: In principle, this text includes all genders. For better readability, however, only one gender form is used.

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